InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cadps

Summary

InnateDB Protein

IDBP-255541.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cadps

Protein Name

Ca2+-dependent secretion activator

Synonyms

AU067781; CAPS; CAPS1; mKIAA1121;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108277

InnateDB Gene

IDBG-132306 (Cadps)

Protein Structure

UniProt Annotation

Function

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell junction, synapse {ECO:0000250}. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. May preferentially binds to DCVs but not to SVs. Probably localizes to different vesicles compared to CADPS2. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. {ECO:0000269PubMed:14530279, ECO:0000269PubMed:15820695}.

Disease Associations

Tissue Specificity

Present in brain and adrenal glands (at protein level). Specifically expressed in neural and endocrine secretory tissues. Strongly expressed in almost all nerve cells of the brain, although it is absent from glial cells. Expressed in the cardiac atria, but not ventricles. {ECO:0000269PubMed:14530279, ECO:0000269PubMed:15820695, ECO:0000269PubMed:17984325}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.