InnateDB Protein
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IDBP-255559.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rpap2
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Protein Name
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RNA polymerase II associated protein 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108273
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InnateDB Gene
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IDBG-187173 (Rpap2)
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Protein Structure
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Function |
Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
45 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2141142
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InterPro |
IPR007308
Protein of unknown function DUF408
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PFAM |
PF04181
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VC34
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PhosphoSite |
PhosphoSite-Q8VC34
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
231571
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UniGene |
Mm.482420
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RefSeq |
NP_001156933
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MGI ID |
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MGI Symbol |
Rpap2
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OMIM |
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CCDS |
CCDS51588
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HPRD |
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IMGT |
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EMBL |
AK034418
AK049889
AK145830
AK161901
AK166574
BC021895
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GenPept |
AAH21895
BAC28703
BAC33973
BAE26681
BAE36627
BAE38864
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