Version 5.4
Mus musculus Protein: Galnt13
Summary
InnateDB Protein IDBP-255596.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Galnt13
Protein Name UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000108255
InnateDB Gene IDBG-171430 (Galnt13)
Protein Structure
UniProt Annotation
Function Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a much stronger activity than GALNT1 to transfer GalNAc to mucin peptides, such as Muc5Ac and Muc7. Able to glycosylate SDC3. Probably responsible for the synthesis of Tn antigen in neuronal cells. {ECO:0000269PubMed:12407114, ECO:0000269PubMed:8618846}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Specifically expressed in neuronal cells. Not expressed in glial cells such as astrocytes. Expressed at low level. {ECO:0000269PubMed:12407114, ECO:0000269PubMed:12651884}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006493 protein O-linked glycosylation
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2139447
InterPro IPR000772 Ricin B lectin domain
IPR001173 Glycosyltransferase 2-like
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF00652
PF14200
PF00535
PRINTS
PIRSF
SMART SM00458
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CF93
PhosphoSite PhosphoSite-Q8CF93
TrEMBL B1AY79
UniProt Splice Variant
Entrez Gene 271786
UniGene Mm.487482
RefSeq XP_006498150
MGI ID
MGI Symbol Galnt13
OMIM
CCDS CCDS16041
HPRD
IMGT
EMBL AB082928 AK038387 AK045417 AL844865 AL844895 AL845426 AL929113 BC131651 BC131652 BX321901 CH466519
GenPept AAI31652 AAI31653 BAC29981 BAC32353 BAC54546 EDL26919 EDL26920 EDL26922

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca