InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nek10

Summary

InnateDB Protein

IDBP-255618.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nek10

Protein Name

NIMA (never in mitosis gene a)- related kinase 10

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108249

InnateDB Gene

IDBG-133091 (Nek10)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0031954	positive regulation of protein autophosphorylation
GO:0043406	positive regulation of MAP kinase activity
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:1902749	regulation of cell cycle G2/M phase transition

Cellular Component

GO:0005575	cellular_component
GO:1902911	protein kinase complex

Protein Structure and Domains

PDB ID

MGI:2685128

InterPro

IPR000225 Armadillo
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR002575 Aminoglycoside phosphotransferase
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00514
PF00069
PF07714
PF01636

PRINTS

PR00109

PIRSF

SMART

SM00185
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt