InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dpp10

Summary

InnateDB Protein

IDBP-255643.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dpp10

Protein Name

dipeptidylpeptidase 10

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108225

InnateDB Gene

IDBG-188529 (Dpp10)

Protein Structure

UniProt Annotation

Function

Has no dipeptidyl aminopeptidase activity. May modulate cell surface expression and activity of the potassium channels KCND1 and KCND2 (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the brain, predominantly by neurons and not by glia. {ECO:0000269PubMed:15671030}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2442409

InterPro

IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR002469 Peptidase S9B, dipeptidylpeptidase IV N-terminal
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00326
PF00930

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6NXK7

PhosphoSite