InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kdm5c

Summary

InnateDB Protein

IDBP-255674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kdm5c

Protein Name

lysine (K)-specific demethylase 5C

Synonyms

D930009K15Rik; Jarid1c; mKIAA0234; Smcx;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108203

InnateDB Gene

IDBG-180176 (Kdm5c)

Protein Structure

UniProt Annotation

Function

Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00355, ECO:0000255PROSITE-ProRule:PRU00537}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0032453	histone demethylase activity (H3-K4 specific)

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0034720	histone H3-K4 demethylation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

MGI:99781

InterPro

IPR001606 ARID/BRIGHT DNA-binding domain
IPR001965 Zinc finger, PHD-type
IPR003347 JmjC domain
IPR003349 Transcription factor jumonji, JmjN
IPR004198 Zinc finger, C5HC2-type
IPR011011 Zinc finger, FYVE/PHD-type
IPR013637 Lysine-specific demethylase-like domain
IPR019787 Zinc finger, PHD-finger

PFAM