InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acpp

Summary

InnateDB Protein

IDBP-255684.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acpp

Protein Name

acid phosphatase, prostate

Synonyms

5\'-NT; A030005E02Rik; FRAP; Lap; PAP; Ppal;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108209

InnateDB Gene

IDBG-194945 (Acpp)

Protein Structure

UniProt Annotation

Function

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity). {ECO:0000250}.Isoform 2: the cellular form also has ecto-5'- nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. {ECO:0000269PubMed:18940592}.

Subcellular Localization

Isoform 1: Secreted {ECO:0000250}.Isoform 2: Cell membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the lysosome membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in salivary gland, thymus and thyroid gland. Isoform 2 is widely expressed in prostate lobes, brain, kidney, liver, lung, muscle, placenta, salivary gland, spleen, thyroid and thymus. Locates to Schwann cells and fibroblasts. Expressed in peptidergic and non- peptidergic nociceptive (pain-sensing) neurons. Preferentially expressed in non-peptidergic doral root ganglia neurons. {ECO:0000269PubMed:17638863, ECO:0000269PubMed:18940592, ECO:0000269PubMed:20084276}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003993	acid phosphatase activity
GO:0008253	5'-nucleotidase activity
GO:0016791	phosphatase activity
GO:0033265	choline binding
GO:0042131	thiamine phosphate phosphatase activity
GO:0042803	protein homodimerization activity
GO:0052642	lysophosphatidic acid phosphatase activity

Biological Process

GO:0006144	purine nucleobase metabolic process
GO:0006772	thiamine metabolic process
GO:0009117	nucleotide metabolic process
GO:0016311	dephosphorylation
GO:0046085	adenosine metabolic process
GO:0051930	regulation of sensory perception of pain
GO:0060168	positive regulation of adenosine receptor signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005765	lysosomal membrane
GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0012506	vesicle membrane
GO:0016021	integral component of membrane
GO:0030141	secretory granule
GO:0030175	filopodium
GO:0031985	Golgi cisterna
GO:0045177	apical part of cell