InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apobec1

Summary

InnateDB Protein

IDBP-255699.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apobec1

Protein Name

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

Synonyms

Cdar1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108205

InnateDB Gene

IDBG-185598 (Apobec1)

Protein Structure

UniProt Annotation

Function

Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. {ECO:0000269PubMed:21496894}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the spleen. Expressed at lower level in the kidney, testis, lung, brain and liver. {ECO:0000269PubMed:12859895}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0017091	AU-rich element binding

Biological Process

GO:0006397	mRNA processing
GO:0006970	response to osmotic stress
GO:0010043	response to zinc ion
GO:0010332	response to gamma radiation
GO:0016554	cytidine to uridine editing
GO:0016556	mRNA modification
GO:0032869	cellular response to insulin stimulus
GO:0042127	regulation of cell proliferation
GO:0042157	lipoprotein metabolic process
GO:0042158	lipoprotein biosynthetic process
GO:0042493	response to drug
GO:0042953	lipoprotein transport
GO:0045471	response to ethanol
GO:0048255	mRNA stabilization
GO:0051592	response to calcium ion
GO:0051607	defense response to virus
GO:0080111	DNA demethylation
GO:0090310	negative regulation of methylation-dependent chromatin silencing