Version 5.4
Mus musculus Protein: Cd163
Summary
InnateDB Protein IDBP-255789.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd163
Protein Name CD163 antigen
Synonyms CD163v2; CD163v3;
Species Mus musculus
Ensembl Protein ENSMUSP00000108160
InnateDB Gene IDBG-186721 (Cd163)
Protein Structure
UniProt Annotation
Function Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium- dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). {ECO:0000250}.After shedding, the soluble form (sCD163) may play an anti-inflammatory role. {ECO:0000250}.
Subcellular Localization Soluble CD163: Secreted {ECO:0000250}.Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen and mesenteric lymph nodes. {ECO:0000269PubMed:11345593}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0006953 acute-phase response
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2135946
InterPro IPR001190 SRCR domain
IPR017448 SRCR-like domain
PFAM PF00530
PRINTS PR00258
PIRSF
SMART SM00202
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2VLH6
PhosphoSite PhosphoSite-Q2VLH6
TrEMBL B7ZMW6
UniProt Splice Variant
Entrez Gene 93671
UniGene Mm.37426
RefSeq NP_001163866
MGI ID
MGI Symbol Cd163
OMIM
CCDS CCDS51905
HPRD
IMGT
EMBL AF274883 BC144848 BC145793 CH466523 DQ058616 DQ058617
GenPept AAI44849 AAI45794 AAK16065 AAY99763 AAY99764 EDK99729

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca