InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptpn6

Summary

InnateDB Protein

IDBP-255913.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptpn6

Protein Name

protein tyrosine phosphatase, non-receptor type 6

Synonyms

70Z-SHP; hcp; Hcph; me; Ptp1C; PTPTY-42; SH-PTP1; SHP-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108103

InnateDB Gene

IDBG-187635 (Ptpn6)

Protein Structure

UniProt Annotation

Function

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. {ECO:0000269PubMed:9528781}.

Subcellular Localization

Cytoplasm. Nucleus {ECO:0000250}. Note=In neurons, translocates into the nucleus after treatment with angiotensin II. Shuttles between the cytoplasm and nucleus via its association with PDPK1 (By similarity). {ECO:0000250}.

Disease Associations

Note=Defects in Ptpn6 are the cause of the motheaten (me) or viable motheaten (mev) phenotypes. Mice homozygous for the recessive allelic mutations develop severe defects in hematopoiesis.

Tissue Specificity

Expressed predominantly in hematopoietic cells. {ECO:0000269PubMed:1932742}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	58 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding
GO:0042169	SH2 domain binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006470	protein dephosphorylation
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016311	dephosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030154	cell differentiation
GO:0030220	platelet formation
GO:0033277	abortive mitotic cell cycle
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0035556	intracellular signal transduction
GO:0035855	megakaryocyte development
GO:0042130	negative regulation of T cell proliferation
GO:0042267	natural killer cell mediated cytotoxicity
GO:0043407	negative regulation of MAP kinase activity
GO:0043409	negative regulation of MAPK cascade
GO:0045577	regulation of B cell differentiation
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0050853	B cell receptor signaling pathway
GO:0050859	negative regulation of B cell receptor signaling pathway
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0051279	regulation of release of sequestered calcium ion into cytosol
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0070527	platelet aggregation
GO:2000045	regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005911	cell-cell junction
GO:0042105	alpha-beta T cell receptor complex

Protein Structure and Domains

PDB ID

MGI:96055

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR000980 SH2 domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR012152 Protein-tyrosine phosphatase, non-receptor type-6, -11
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00017
PF14633

PRINTS

PR00700
PR00401

PIRSF

PIRSF000929

SMART

SM00194
SM00252
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References