InnateDB Protein
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IDBP-255930.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fcamr
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Protein Name
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Fc receptor, IgA, IgM, high affinity
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108096
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InnateDB Gene
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IDBG-190443 (Fcamr)
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Protein Structure
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Function |
Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM. {ECO:0000269PubMed:11062505}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:11062505}; Single-pass type I membrane protein {ECO:0000269PubMed:11062505}.
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Disease Associations |
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Tissue Specificity |
Expressed in several tissues including thymus, spleen, liver, kidney, small and large intestine, testis and placenta. Expressed by oligodendrocytes, B-cells and macrophages but not granulocytes, T-cells or NK cells (at protein level). {ECO:0000269PubMed:11062505, ECO:0000269PubMed:12527391}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1927803
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InterPro |
IPR003599
Immunoglobulin subtype
IPR013106
Immunoglobulin V-set domain
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PFAM |
PF07686
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PRINTS |
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PIRSF |
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SMART |
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
Q2TB54
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PhosphoSite |
PhosphoSite-Q2TB54
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
64435
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UniGene |
Mm.31821
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RefSeq |
NP_001164103
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MGI ID |
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MGI Symbol |
Fcamr
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OMIM |
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CCDS |
CCDS48353
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HPRD |
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IMGT |
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EMBL |
AB048834
AB071978
BC110549
BC110550
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GenPept |
AAI10550
AAI10551
BAB17312
BAB71750
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