InnateDB Protein
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IDBP-256067.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ing4
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Protein Name
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inhibitor of growth family, member 4
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Synonyms
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D6Wsu147e; D6Xrf92; p29ING4;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108036
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InnateDB Gene
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IDBG-188872 (Ing4)
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Protein Structure
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Function |
Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
21 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:107307
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8C0D7
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PhosphoSite |
PhosphoSite-Q8C0D7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
28019
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UniGene |
Mm.399689
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RefSeq |
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MGI ID |
1WEU
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MGI Symbol |
Ing4
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK002821
AK009267
AK031633
AK050522
AY035880
AY035881
AY036107
BC009127
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GenPept |
AAH09127
AAK63168
AAK63169
AAK64509
BAB26183
BAC25009
BAC27489
BAC34304
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