InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rbp4

Summary

InnateDB Protein

IDBP-256234.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rbp4

Protein Name

retinol binding protein 4, plasma

Synonyms

Rbp-4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107954

InnateDB Gene

IDBG-162693 (Rbp4)

Protein Structure

UniProt Annotation

Function

Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016918	retinal binding
GO:0019841	retinol binding
GO:0034632	retinol transporter activity

Biological Process

GO:0001654	eye development
GO:0006094	gluconeogenesis
GO:0007283	spermatogenesis
GO:0007507	heart development
GO:0008584	male gonad development
GO:0030324	lung development
GO:0032868	response to insulin
GO:0034633	retinol transport
GO:0042572	retinol metabolic process
GO:0042574	retinal metabolic process
GO:0048562	embryonic organ morphogenesis
GO:0048706	embryonic skeletal system development
GO:0048738	cardiac muscle tissue development
GO:0048807	female genitalia morphogenesis
GO:0050908	detection of light stimulus involved in visual perception
GO:0051024	positive regulation of immunoglobulin secretion
GO:0060041	retina development in camera-type eye
GO:0060044	negative regulation of cardiac muscle cell proliferation
GO:0060059	embryonic retina morphogenesis in camera-type eye
GO:0060065	uterus development
GO:0060068	vagina development
GO:0060157	urinary bladder development
GO:0060347	heart trabecula formation

Cellular Component

GO:0005615

extracellular space

Protein Structure and Domains

PDB ID

MGI:97879

InterPro

IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR002345 Lipocalin
IPR002449 Retinol binding protein/Purpurin
IPR003057 Invertebrate colouration protein
IPR011038 Calycin-like
IPR022271 Lipocalin, ApoD type

PFAM

PF00061
PF08212

PRINTS

PR00179
PR01174
PR01273

PIRSF

PIRSF500204
PIRSF036893

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt