InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Selk

Summary

InnateDB Protein

IDBP-256375.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Selk

Protein Name

selenoprotein K

Synonyms

1110001C03Rik; AA673253; Hsp30; HSPC030;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107887

InnateDB Gene

IDBG-142010 (Selk)

Protein Structure

UniProt Annotation

Function

Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Plays a role in protection of cells from ER stress- induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes. {ECO:0000269PubMed:21220695, ECO:0000269PubMed:23444136}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:21220695}; Single-pass membrane protein {ECO:0000269PubMed:21220695}. Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

High expression in spleen and intestine (at protein level). Expressed in a range of immune cells including T and B-cells and also in myeloid cells including macrophages, neutrophils and dendritic cells (at protein level). {ECO:0000269PubMed:21220695, ECO:0000269PubMed:21849499}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0006816	calcium ion transport
GO:0006979	response to oxidative stress
GO:0010742	macrophage derived foam cell differentiation
GO:0018345	protein palmitoylation
GO:0030335	positive regulation of cell migration
GO:0042102	positive regulation of T cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0045728	respiratory burst after phagocytosis
GO:0051223	regulation of protein transport
GO:2000406	positive regulation of T cell migration