InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpm6b

Summary

InnateDB Protein

IDBP-256443.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpm6b

Protein Name

glycoprotein m6b

Synonyms

AI593561; Gpm6; M6B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107843

InnateDB Gene

IDBG-185221 (Gpm6b)

Protein Structure

UniProt Annotation

Function

May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. {ECO:0000269PubMed:18581270}.

Subcellular Localization

Membrane; Multi-pass membrane protein. Cell membrane. Note=Colocalizes with SERT at the plasma membrane.

Disease Associations

Tissue Specificity

Widely expressed. In the brain, expressed in neurons and oligodendrocytes. {ECO:0000269PubMed:11749036}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001503	ossification
GO:0015031	protein transport
GO:0030501	positive regulation of bone mineralization
GO:0032956	regulation of actin cytoskeleton organization
GO:0051612	negative regulation of serotonin uptake
GO:0051893	regulation of focal adhesion assembly
GO:0085029	extracellular matrix assembly
GO:2000009	negative regulation of protein localization to cell surface