InnateDB Protein
|
IDBP-256509.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Tchp
|
Protein Name
|
trichoplein, keratin filament binding
|
Synonyms
|
A930031F18Rik; AV279199;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000107818
|
InnateDB Gene
|
IDBG-192768 (Tchp)
|
Protein Structure
|
|
Function |
Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Mitochondrion {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in all tissues examined, including brain, liver, small intestine, large intestine, lung and heart. Found concentrated in tubular structures within hepatocytes, and in the apical cortical region and desmosomes of the apical junctional domain in enterocytes of the small intestine. In the hair follicle, localized at the outer root sheath. Also expressed in blood vessels (at protein level). {ECO:0000269PubMed:15731013}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
6 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1925082
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q3TVW5
|
PhosphoSite |
PhosphoSite-Q3TVW5
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
77832
|
UniGene |
Mm.239698
|
RefSeq |
XP_006530573
|
MGI ID |
|
MGI Symbol |
Tchp
|
OMIM |
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
AK020912
AK083027
AK159947
BC043048
BC047930
|
GenPept |
AAH43048
AAH47930
BAB32251
BAC38735
BAE35503
|
|
|