Version 5.4
| Mus musculus Protein: Frmpd4 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-256619.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Frmpd4 | ||||||
| Protein Name | FERM and PDZ domain containing 4 | ||||||
| Synonyms | |||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000107775 | ||||||
| InnateDB Gene | IDBG-185601 (Frmpd4) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | Positive regulator of dendritic spine morphogenesis and density (By similarity). Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5- bisphosphate (By similarity). {ECO:0000250}. | ||||||
| Subcellular Localization | Cell projection, dendritic spine {ECO:0000250}. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Expressed in various regions of the brain, including cortex, hippocampus, cerebellum, olfactory bulb and medial habenular nucleus. {ECO:0000269PubMed:19118189}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:3042378 | ||||||
| InterPro |
IPR000299
FERM domain IPR001202 WW domain IPR001478 PDZ domain IPR019748 FERM central domain IPR019749 Band 4.1 domain IPR029071 Ubiquitin-related domain |
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| PFAM |
PF00397
PF00595 PF13180 PF00373 |
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| PRINTS | |||||||
| PIRSF | |||||||
| SMART |
SM00456
SM00228 SM00295 |
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| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | A2AFR3 | ||||||
| PhosphoSite | PhosphoSite-A2AFR3 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 333605 | ||||||
| UniGene | Mm.426168 | ||||||
| RefSeq | NP_001277356 | ||||||
| MGI ID | |||||||
| MGI Symbol | Frmpd4 | ||||||
| OMIM | |||||||
| CCDS | CCDS41210 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AK122244 AK147370 AK147440 AL672186 AL807744 AL807773 BC139429 BX546498 | ||||||
| GenPept | AAI39430 BAC65526 BAE27868 BAE27913 CAM16366 CAM17768 CAM17769 CAM17770 CAM18047 CAM18048 CAM18049 CAM24062 | ||||||