InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pzp

Summary

InnateDB Protein

IDBP-256654.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pzp

Protein Name

pregnancy zone protein

Synonyms

A1m; A2m; AI893533; MAM;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107760

InnateDB Gene

IDBG-191247 (Pzp)

Protein Structure

UniProt Annotation

Function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highest expression in liver, medium expression in ovary, heart and stomach. Low expression in lung, kidney and uterus. Protein found in plasma. {ECO:0000269PubMed:15355875}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0032403	protein complex binding

Biological Process

GO:0007566	embryo implantation
GO:0010951	negative regulation of endopeptidase activity

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

MGI:87854

InterPro

IPR001599 Alpha-2-macroglobulin
IPR002890 Alpha-2-macroglobulin, N-terminal
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
IPR009048 Alpha-macroglobulin, receptor-binding
IPR011625 Alpha-2-macroglobulin, N-terminal 2
IPR011626 Alpha-macroglobulin complement component
IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming

PFAM

PF00207
PF01835
PF07677
PF07703
PF07678
PF10569

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61838

PhosphoSite