InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itga6

Summary

InnateDB Protein

IDBP-256709.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itga6

Protein Name

integrin alpha 6

Synonyms

5033401O05Rik; AI115430; Cd49f; VLA-6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107729

InnateDB Gene

IDBG-179059 (Itga6)

Protein Structure

UniProt Annotation

Function

Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Mice expressing a null mutation of the alpha-6 subunit gene die soon after birth and develop severe blistering. The blisters are due to separation of the basal epithelial cells from a normally formed basement membrane.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0043236	laminin binding
GO:0046872	metal ion binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0010811	positive regulation of cell-substrate adhesion
GO:0016337	single organismal cell-cell adhesion
GO:0022409	positive regulation of cell-cell adhesion
GO:0031668	cellular response to extracellular stimulus
GO:0033627	cell adhesion mediated by integrin
GO:0042327	positive regulation of phosphorylation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043065	positive regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046847	filopodium assembly
GO:0050873	brown fat cell differentiation
GO:0050900	leukocyte migration
GO:0071407	cellular response to organic cyclic compound
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005604	basement membrane
GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009925	basal plasma membrane
GO:0009986	cell surface
GO:0016323	basolateral plasma membrane
GO:0030056	hemidesmosome
GO:0030175	filopodium
GO:0034676	alpha6-beta4 integrin complex
GO:0045178	basal part of cell