InnateDB Protein
|
IDBP-256907.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Atf2
|
Protein Name
|
activating transcription factor 2
|
Synonyms
|
Atf-2; CRE-BP; Creb2; D130078H02Rik; D18875; mXBP; Tg(Gzma-Klra1)7Wum;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000107638
|
InnateDB Gene
|
IDBG-180520 (Atf2)
|
Protein Structure
|
|
Function |
Transcriptional activator which regulates the transcription of various genes, including those involved in anti- apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Nucleus. Cytoplasm {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Note=Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-34 is required for its nuclear localization and negatively regulates its mitochondrial localization. Colocalizes with the MRN complex in the IR-induced foci (IRIF) (By similarity). {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 208 interaction(s) predicted by orthology.
Experimentally validated |
Total |
41
[view]
|
Protein-Protein |
29
[view]
|
Protein-DNA |
12
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
208 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0000980
|
RNA polymerase II distal enhancer sequence-specific DNA binding
|
GO:0001077
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
|
GO:0001102
|
RNA polymerase II activating transcription factor binding
|
GO:0003677
|
DNA binding
|
GO:0003682
|
chromatin binding
|
GO:0003700
|
sequence-specific DNA binding transcription factor activity
|
GO:0004402
|
histone acetyltransferase activity
|
GO:0005515
|
protein binding
|
GO:0008140
|
cAMP response element binding protein binding
|
GO:0019901
|
protein kinase binding
|
GO:0035497
|
cAMP response element binding
|
GO:0043565
|
sequence-specific DNA binding
|
GO:0046872
|
metal ion binding
|
GO:0046982
|
protein heterodimerization activity
|
|
Biological Process |
GO:0003151
|
outflow tract morphogenesis
|
GO:0006351
|
transcription, DNA-templated
|
GO:0006355
|
regulation of transcription, DNA-templated
|
GO:0006970
|
response to osmotic stress
|
GO:0006974
|
cellular response to DNA damage stimulus
|
GO:0016573
|
histone acetylation
|
GO:0031573
|
intra-S DNA damage checkpoint
|
GO:0032915
|
positive regulation of transforming growth factor beta2 production
|
GO:0045444
|
fat cell differentiation
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
GO:0051091
|
positive regulation of sequence-specific DNA binding transcription factor activity
|
GO:0060612
|
adipose tissue development
|
GO:1902110
|
positive regulation of mitochondrial membrane permeability involved in apoptotic process
|
|
Cellular Component |
|
PDB ID |
MGI:109349
|
InterPro |
IPR004827
Basic-leucine zipper domain
IPR016378
Transcription factor, cyclic AMP-dependent
|
PFAM |
PF00170
PF07716
|
PRINTS |
|
PIRSF |
PIRSF003153
|
SMART |
SM00338
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P16951
|
PhosphoSite |
PhosphoSite-P16951
|
TrEMBL |
Q8BQY2
|
UniProt Splice Variant |
|
Entrez Gene |
11909
|
UniGene |
Mm.406406
|
RefSeq |
NP_033845
|
MGI ID |
|
MGI Symbol |
Atf2
|
OMIM |
|
CCDS |
CCDS16135
|
HPRD |
|
IMGT |
|
EMBL |
AF483482
AF483483
AK046184
AK051591
AY902311
CH466519
M31629
S76655
S76657
S76659
|
GenPept |
AAA39780
AAB21127
AAB21128
AAB21129
AAL90756
AAL90757
AAX83926
BAC32623
BAC34684
EDL27148
EDL27150
|
|
|