InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smarcc1

Summary

InnateDB Protein

IDBP-256965.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smarcc1

Protein Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1

Synonyms

AI115498; BAF155; Rsc8; SRG3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107600

InnateDB Gene

IDBG-201862 (Smarcc1)

Protein Structure

UniProt Annotation

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. {ECO:0000250, ECO:0000269PubMed:11604513, ECO:0000269PubMed:17640523}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Highly expressed in adult brain, testis and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 98 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	40 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	98 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006323	DNA packaging
GO:0006337	nucleosome disassembly
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0007399	nervous system development
GO:0008286	insulin receptor signaling pathway
GO:0009887	organ morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0001741	XY body
GO:0005622	intracellular
GO:0005634	nucleus
GO:0016514	SWI/SNF complex
GO:0071564	npBAF complex
GO:0071565	nBAF complex
GO:0071778	WINAC complex

Protein Structure and Domains

PDB ID

MGI:1203524

InterPro

IPR000953 Chromo domain/shadow
IPR001005 SANT/Myb domain
IPR001357 BRCT domain
IPR007526 SWIRM domain
IPR009057 Homeodomain-like
IPR017877 Myb-like domain

PFAM

PF00249
PF00533
PF12738
PF04433

PRINTS

PIRSF

SMART

SM00298
SM00717
SM00292

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97496

PhosphoSite

PhosphoSite-P97496

TrEMBL

UniProt Splice Variant

Entrez Gene

20588

UniGene

Mm.85410

RefSeq

MGI ID

MGI Symbol

Smarcc1

OMIM

CCDS

HPRD

IMGT

EMBL

BC052423 BC053064 U85614

GenPept

AAB42085 AAH52423 AAH53064