InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ttn

Summary

InnateDB Protein

IDBP-257117.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Ttn

Protein Name

titin

Synonyms

1100001C23Rik; 2310036G12Rik; 2310057K23Rik; 2310074I15Rik; AF006999; AV006427; D330041I19Rik; D830007G01Rik; L56; mdm; shru;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107477

InnateDB Gene

IDBG-182351 (Ttn)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 95 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	95 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003676	nucleic acid binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005200	structural constituent of cytoskeleton
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008307	structural constituent of muscle
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0043621	protein self-association
GO:0051015	actin filament binding
GO:0051371	muscle alpha-actinin binding

Biological Process

GO:0001701	in utero embryonic development
GO:0003007	heart morphogenesis
GO:0003300	cardiac muscle hypertrophy
GO:0006468	protein phosphorylation
GO:0006936	muscle contraction
GO:0007076	mitotic chromosome condensation
GO:0007512	adult heart development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030240	skeletal muscle thin filament assembly
GO:0030241	skeletal muscle myosin thick filament assembly
GO:0035023	regulation of Rho protein signal transduction
GO:0043056	forward locomotion
GO:0045214	sarcomere organization
GO:0045859	regulation of protein kinase activity
GO:0048739	cardiac muscle fiber development
GO:0048769	sarcomerogenesis
GO:0051592	response to calcium ion
GO:0055002	striated muscle cell development
GO:0055003	cardiac myofibril assembly
GO:0055008	cardiac muscle tissue morphogenesis
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0005794	Golgi apparatus
GO:0005859	muscle myosin complex
GO:0005865	striated muscle thin filament
GO:0030017	sarcomere
GO:0030018	Z disc
GO:0031430	M band
GO:0031672	A band
GO:0031674	I band

Protein Structure and Domains

PDB ID

MGI:98864

InterPro

IPR000219 Dbl homology (DH) domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR004168 PPAK motif
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR012337 Ribonuclease H-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR015129 Titin Z
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR022682 Peptidase C2, calpain, large subunit, domain III

PFAM