InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccrl2

Summary

InnateDB Protein

IDBP-257176.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccrl2

Protein Name

chemokine (C-C motif) receptor-like 2

Synonyms

1810047I05Rik; Ackr5; CCR11; Cmkbr1l2; E01; L-CCR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107519

InnateDB Gene

IDBG-202675 (Ccrl2)

Protein Structure

UniProt Annotation

Function

Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in macrophages, astrocytes, in glial cells. Constitutively expressed by mast cells. Detected in bronchial epithelium in OVA-induced airway inflammation. Up- regulated during dendritic cell (DC) maturation. {ECO:0000269PubMed:12555200, ECO:0000269PubMed:14966207, ECO:0000269PubMed:14999816, ECO:0000269PubMed:20606167, ECO:0000269PubMed:9563519}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0016493	C-C chemokine receptor activity
GO:0042379	chemokine receptor binding
GO:0048020	CCR chemokine receptor binding

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0070098	chemokine-mediated signaling pathway