Version 5.4
Mus musculus Protein: Styx
Summary
InnateDB Protein IDBP-257277.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Styx
Protein Name serine/threonine/tyrosine interaction protein
Synonyms 0610039A20Rik; hStyxb;
Species Mus musculus
Ensembl Protein ENSMUSP00000107466
InnateDB Gene IDBG-153214 (Styx)
Protein Structure
UniProt Annotation
Function Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Seems to play a role in spermiogenesis. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Little staining visible in the cytosol. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in muscle, testis and brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0007283 spermatogenesis
GO:0016311 dephosphorylation
GO:0045204 MAPK export from nucleus
GO:0070372 regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1891150
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00782
PRINTS
PIRSF
SMART SM00195
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60969
PhosphoSite PhosphoSite-Q60969
TrEMBL Q5U4H6
UniProt Splice Variant
Entrez Gene 56291
UniGene
RefSeq NP_062611
MGI ID
MGI Symbol Styx
OMIM
CCDS CCDS26975
HPRD
IMGT
EMBL AK002822 AK030122 AK042741 AK046970 AK166043 BC038608 BC085089 BC096674 U34973
GenPept AAA87036 AAA87037 AAH38608 AAH85089 AAH96674 BAB22384 BAC26793 BAC32931 BAE38539 BAE43317

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca