Version 5.4
Mus musculus Protein: Sh3pxd2a
Summary
InnateDB Protein IDBP-257350.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh3pxd2a
Protein Name SH3 and PX domains 2A
Synonyms 2310014D11Rik; AA589508; AI256723; AI413738; C230050L11; EG329070; Fish; Gm5098; Sh3md1; Tks5; TSK5;
Species Mus musculus
Ensembl Protein ENSMUSP00000107430
InnateDB Gene IDBG-174586 (Sh3pxd2a)
Protein Structure
UniProt Annotation
Function Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Cell projection, podosome {ECO:0000250}. Note=Cytoplasmic in normal cells and localizes to podosomes in Src-transformed cells. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Not found in the spleen and testis. {ECO:0000269PubMed:9687503}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006801 superoxide metabolic process
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0002102 podosome
GO:0005737 cytoplasm
GO:0030054 cell junction
GO:0042995 cell projection
Protein Structure and Domains
PDB ID MGI:1298393
InterPro IPR001452 SH3 domain
IPR001683 Phox homologous domain
IPR011511 Variant SH3 domain
PFAM PF00018
PF14604
PF00787
PF07653
PRINTS PR00452
PIRSF
SMART SM00326
SM00312
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O89032
PhosphoSite PhosphoSite-O89032
TrEMBL
UniProt Splice Variant
Entrez Gene 14218
UniGene Mm.481475
RefSeq NP_001158189
MGI ID
MGI Symbol Sh3pxd2a
OMIM
CCDS CCDS50464
HPRD
IMGT
EMBL AC132268 AC132288 AJ007012 BC118022
GenPept AAI18023 CAA07416

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca