Version 5.4
Mus musculus Protein: Tor1aip2
Summary
InnateDB Protein IDBP-257457.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tor1aip2
Protein Name torsin A interacting protein 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000107387
InnateDB Gene IDBG-200150 (Tor1aip2)
Protein Structure
UniProt Annotation
Function Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Nucleus envelope {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the spinal cord and liver (at protein level). {ECO:0000269PubMed:16364897}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001671 ATPase activator activity
GO:0005515 protein binding
GO:0051117 ATPase binding
Biological Process
GO:0007029 endoplasmic reticulum organization
GO:0032781 positive regulation of ATPase activity
Cellular Component
GO:0005635 nuclear envelope
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:3582695
InterPro IPR008662 Lamina-associated polypeptide 1C
PFAM PF05609
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BYU6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 240832
UniGene Mm.458051
RefSeq NP_766431
MGI ID
MGI Symbol Tor1aip2
OMIM
CCDS CCDS15389
HPRD
IMGT
EMBL AK038024 AK080959 BC066790
GenPept AAH66790 BAC29923 BAC38096

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca