InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OXSR1

Summary

InnateDB Protein

IDBP-25755.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OXSR1

Protein Name

oxidative-stress responsive 1

Synonyms

OSR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000311713

InnateDB Gene

IDBG-25753 (OXSR1)

Protein Structure

UniProt Annotation

Function

Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton. {ECO:0000269PubMed:14707132, ECO:0000303PubMed:14707132}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:22361696}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in all tissue examined. {ECO:0000269PubMed:10083736}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	28 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006979	response to oxidative stress
GO:0018107	peptidyl-threonine phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0035556	intracellular signal transduction
GO:0071476	cellular hypotonic response
GO:1901017	negative regulation of potassium ion transmembrane transporter activity
GO:1901380	negative regulation of potassium ion transmembrane transport
GO:2000681	negative regulation of rubidium ion transport
GO:2000687	negative regulation of rubidium ion transmembrane transporter activity

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain

PFAM

PF00069
PF07714
PF12202

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt