Version 5.4
Mus musculus Protein: Stk38l
Summary
InnateDB Protein IDBP-257684.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stk38l
Protein Name serine/threonine kinase 38 like
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000107271
InnateDB Gene IDBG-198429 (Stk38l)
Protein Structure
UniProt Annotation
Function Involved in the regulation of structural processes in differentiating and mature neuronal cells. {ECO:0000269PubMed:15308672, ECO:0000269PubMed:21730291}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15308672}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:15308672}. Membrane {ECO:0000269PubMed:15308672}. Note=Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.
Disease Associations
Tissue Specificity Highly expressed in the large and small intestine, stomach and testis. High levels also present in the brain, in particular the neurocortex, basal forebrain, hippocampus, the amygdala, cerebellum and brainstem. {ECO:0000269PubMed:15037617, ECO:0000269PubMed:15308672}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003779 actin binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0035556 intracellular signal transduction
GO:0051128 regulation of cellular component organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID MGI:1922250
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PF00433
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TSE6
PhosphoSite PhosphoSite-AAP44998
TrEMBL
UniProt Splice Variant
Entrez Gene 232533
UniGene Mm.418640
RefSeq
MGI ID
MGI Symbol Stk38l
OMIM
CCDS
HPRD
IMGT
EMBL AK052288 AY223819 AY292400 BC062170 CH466572 CU207394
GenPept AAH62170 AAO66474 AAP44998 BAC34918 CAQ51943 EDL10715

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca