InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Far2

Summary

InnateDB Protein

IDBP-257755.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Far2

Protein Name

fatty acyl CoA reductase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107234

InnateDB Gene

IDBG-198890 (Far2)

Protein Structure

UniProt Annotation

Function

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates. {ECO:0000269PubMed:15220348}.

Subcellular Localization

Peroxisome membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Peroxisome in cells expressing low levels of the protein. Peroxisome and endoplasmic reticulum in cells expressing high levels of the protein (Potential). {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in the meibomian glands of the eyelid and the sebaceous glands of the skin. Expressed in the brain where large quantities of ether lipids are synthesized. {ECO:0000269PubMed:15220348}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050062	long-chain-fatty-acyl-CoA reductase activity
GO:0050662	coenzyme binding
GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006694	steroid biosynthetic process
GO:0009058	biosynthetic process
GO:0010025	wax biosynthetic process
GO:0035336	long-chain fatty-acyl-CoA metabolic process
GO:0044237	cellular metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2687035

InterPro

IPR001509 NAD-dependent epimerase/dehydratase
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR003869 Polysaccharide biosynthesis protein, CapD-like domain
IPR013120 Male sterility, NAD-binding
IPR026055 Fatty acyl-CoA reductase

PFAM

PF01370
PF01073
PF02719
PF07993
PF03015

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7TNT2

PhosphoSite