InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CXCL13

Summary

InnateDB Protein

IDBP-25776.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL13

Protein Name

chemokine (C-X-C motif) ligand 13

Synonyms

ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; SCYB13;

Species

Homo sapiens

Ensembl Protein

ENSP00000286758

InnateDB Gene

IDBG-25774 (CXCL13)

Protein Structure

UniProt Annotation

Function

Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	9 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0017134	fibroblast growth factor binding
GO:0031724	CXCR5 chemokine receptor binding
GO:0031735	CCR10 chemokine receptor binding
GO:0046982	protein heterodimerization activity
GO:0048018	receptor agonist activity
GO:0048248	CXCR3 chemokine receptor binding

Biological Process

GO:0002467	germinal center formation
GO:0002518	lymphocyte chemotaxis across high endothelial venule
GO:0002544	chronic inflammatory response
GO:0002920	regulation of humoral immune response
GO:0006955	immune response
GO:0007166	cell surface receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007267	cell-cell signaling
GO:0010820	positive regulation of T cell chemotaxis
GO:0032861	activation of Rap GTPase activity
GO:0033625	positive regulation of integrin activation
GO:0033634	positive regulation of cell-cell adhesion mediated by integrin
GO:0035754	B cell chemotaxis
GO:0035768	endothelial cell chemotaxis to fibroblast growth factor
GO:0035769	B cell chemotaxis across high endothelial venule
GO:0042742	defense response to bacterium
GO:0045765	regulation of angiogenesis
GO:0048535	lymph node development
GO:2000545	negative regulation of endothelial cell chemotaxis to fibroblast growth factor