Version 5.4
Mus musculus Protein: Caprin2
Summary
InnateDB Protein IDBP-257867.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Caprin2
Protein Name caprin family member 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000107195
InnateDB Gene IDBG-199195 (Caprin2)
Protein Structure
UniProt Annotation
Function May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis. {ECO:0000269PubMed:20516077}.
Subcellular Localization Cytoplasm {ECO:0000250UniProtKB:Q6IMN6}.
Disease Associations
Tissue Specificity Specifically expressed in brain (at protein level). {ECO:0000269PubMed:20516077}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0017148 negative regulation of translation
GO:0030308 negative regulation of cell growth
GO:0032092 positive regulation of protein binding
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050775 positive regulation of dendrite morphogenesis
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID MGI:2448541
InterPro IPR001073 Complement C1q protein
IPR008983 Tumour necrosis factor-like domain
IPR022070 Cytoplasmic activation/proliferation-associated protein-1 C term
PFAM PF00386
PF12287
PRINTS PR00007
PIRSF
SMART SM00110
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q05A80
PhosphoSite PhosphoSite-Q05A80
TrEMBL E4NKG5
UniProt Splice Variant
Entrez Gene 232560
UniGene Mm.422291
RefSeq NP_853519
MGI ID
MGI Symbol Caprin2
OMIM
CCDS CCDS39720
HPRD
IMGT
EMBL AC134542 AK129460 BC092093 BC125373 BC125375 BR000873 CH466572
GenPept AAH92093 AAI25374 AAI25376 BAC98270 EDL10750 FAA00698

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca