Version 5.4
Mus musculus Protein: Dennd5b
Summary
InnateDB Protein IDBP-257889.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dennd5b
Protein Name DENN/MADD domain containing 5B
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000107182
InnateDB Gene IDBG-199339 (Dennd5b)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2444273
InterPro IPR001024 PLAT/LH2 domain
IPR001194 DENN domain
IPR004012 RUN
IPR005112 dDENN domain
IPR005113 uDENN domain
IPR008976 Lipase/lipooxygenase, PLAT/LH2
PFAM PF01477
PF02141
PF02759
PF03455
PF03456
PRINTS
PIRSF
SMART SM00308
SM00799
SM00593
SM00801
SM00800
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2RSQ0
PhosphoSite PhosphoSite-A2RSQ0
TrEMBL E9Q0R9
UniProt Splice Variant
Entrez Gene 320560
UniGene Mm.426874
RefSeq NP_796166
MGI ID
MGI Symbol Dennd5b
OMIM
CCDS CCDS20714
HPRD
IMGT
EMBL AC132412 AC140327 AK050728 AK052296 BC132199 BC132535
GenPept AAI32200 AAI32536 BAC34394 BAC34923

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca