InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptprj

Summary

InnateDB Protein

IDBP-257986.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptprj

Protein Name

protein tyrosine phosphatase, receptor type, J

Synonyms

AI450271; BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2; RPTPJ; Scc-1; Scc1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107121

InnateDB Gene

IDBG-189428 (Ptprj)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0016791	phosphatase activity
GO:0019901	protein kinase binding
GO:0045295	gamma-catenin binding
GO:0051019	mitogen-activated protein kinase binding
GO:0070097	delta-catenin binding

Biological Process

GO:0001570	vasculogenesis
GO:0006470	protein dephosphorylation
GO:0007507	heart development
GO:0008285	negative regulation of cell proliferation
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0016311	dephosphorylation
GO:0030155	regulation of cell adhesion
GO:0030308	negative regulation of cell growth
GO:0030336	negative regulation of cell migration
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0043116	negative regulation of vascular permeability
GO:0043407	negative regulation of MAP kinase activity
GO:0045785	positive regulation of cell adhesion
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048709	oligodendrocyte differentiation
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0050918	positive chemotaxis
GO:0051894	positive regulation of focal adhesion assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0051898	negative regulation of protein kinase B signaling

Cellular Component

GO:0001772	immunological synapse
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0009986	cell surface
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:104574

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003961 Fibronectin, type III
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00041
PF01108

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt