Version 5.4
Mus musculus Protein: Ptprj
Summary
InnateDB Protein IDBP-257988.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptprj
Protein Name protein tyrosine phosphatase, receptor type, J
Synonyms AI450271; BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2; RPTPJ; Scc-1; Scc1;
Species Mus musculus
Ensembl Protein ENSMUSP00000107119
InnateDB Gene IDBG-189428 (Ptprj)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0016791 phosphatase activity
GO:0045295 gamma-catenin binding
GO:0051019 mitogen-activated protein kinase binding
GO:0070097 delta-catenin binding
Biological Process
GO:0001570 vasculogenesis
GO:0006470 protein dephosphorylation
GO:0007507 heart development
GO:0008285 negative regulation of cell proliferation
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0016311 dephosphorylation
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0043116 negative regulation of vascular permeability
GO:0043407 negative regulation of MAP kinase activity
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048709 oligodendrocyte differentiation
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050918 positive chemotaxis
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051898 negative regulation of protein kinase B signaling
Cellular Component
GO:0001772 immunological synapse
GO:0005911 cell-cell junction
GO:0009986 cell surface
Protein Structure and Domains
PDB ID MGI:104574
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003961 Fibronectin, type III
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00102
PF00041
PF01108
PRINTS PR00700
PIRSF
SMART SM00194
SM00404
SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q61373
UniProt Splice Variant
Entrez Gene 19271
UniGene Mm.482815
RefSeq
MGI ID
MGI Symbol Ptprj
OMIM
CCDS
HPRD
IMGT
EMBL AL935132 AL954341 AL954378 D49393
GenPept BAA08386

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca