InnateDB Protein
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IDBP-257993.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Abhd5
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Protein Name
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abhydrolase domain containing 5
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Synonyms
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1300003D03Rik; 2010002J10Rik; CDS; CGI-58; IECN5; NCIE2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000107123
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InnateDB Gene
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IDBG-205933 (Abhd5)
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Protein Structure
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Function |
Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. {ECO:0000269PubMed:16679289}.
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Subcellular Localization |
Cytoplasm. Lipid droplet. Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA.
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Disease Associations |
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Tissue Specificity |
Highly expressed in the adipose tissue and testes. Weakly expressed in the liver, muscle, kidney, and heart. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and hypothalamus in brain (at protein level). {ECO:0000269PubMed:15292255, ECO:0000269PubMed:16679289, ECO:0000269PubMed:18832586}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003841
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1-acylglycerol-3-phosphate O-acyltransferase activity
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GO:0005515
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protein binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1914719
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InterPro |
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9DBL9
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PhosphoSite |
PhosphoSite-Q9DBL9
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TrEMBL |
Q922Z5
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UniProt Splice Variant |
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Entrez Gene |
67469
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UniGene |
Mm.280254
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RefSeq |
XP_006512308
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MGI ID |
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MGI Symbol |
Abhd5
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK004873
AK019488
AK050377
BC006683
BC037063
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GenPept |
AAH06683
AAH37063
BAB23632
BAB31755
BAC34220
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