InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mpzl1

Summary

InnateDB Protein

IDBP-258120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mpzl1

Protein Name

myelin protein zero-like 1

Synonyms

1110007A10Rik; PZR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107062

InnateDB Gene

IDBG-202733 (Mpzl1)

Protein Structure

UniProt Annotation

Function

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 2 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2, may be involved in regulation of integrin-mediated cell motility (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1915731

InterPro

IPR000920 Myelin P0 protein
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain

PFAM

PF07686

PRINTS

PR00213

PIRSF

SMART

SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt