Version 5.4
Mus musculus Protein: Uap1
Summary
InnateDB Protein IDBP-258321.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Uap1
Protein Name UDP-N-acetylglucosamine pyrophosphorylase 1
Synonyms AA420407; AA437972; AgX; AGX-1; AGX-2; AGX1; ESTM38; SPAG2;
Species Mus musculus
Ensembl Protein ENSMUSP00000106982
InnateDB Gene IDBG-203642 (Uap1)
Protein Structure
UniProt Annotation
Function Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity
GO:0016779 nucleotidyltransferase activity
GO:0030246 carbohydrate binding
Biological Process
GO:0006048 UDP-N-acetylglucosamine biosynthetic process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1334459
InterPro IPR002618 UTP--glucose-1-phosphate uridylyltransferase
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF01704
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91YN5
PhosphoSite PhosphoSite-Q91YN5
TrEMBL
UniProt Splice Variant
Entrez Gene 107652
UniGene Mm.433318
RefSeq XP_006496671
MGI ID 1VM8
MGI Symbol Uap1
OMIM
CCDS
HPRD
IMGT
EMBL AK047566 AK049519 AK081690 BC016406 BC017547
GenPept AAH16406 AAH17547 BAC33089 BAC33791 BAC38294

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca