InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CORO1A

Summary

InnateDB Protein

IDBP-25841.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CORO1A

Protein Name

coronin, actin binding protein, 1A

Synonyms

CLABP; CLIPINA; HCORO1; IMD8; p57; TACO;

Species

Homo sapiens

Ensembl Protein

ENSP00000219150

InnateDB Gene

IDBG-25839 (CORO1A)

Protein Structure

UniProt Annotation

Function

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. {ECO:0000269PubMed:10338208}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity). {ECO:0000250}.

Disease Associations

Immunodeficiency 8 (IMD8) [MIM:615401]: A disease of the immune system leading to recurrent infections, and characterized by CD4+ T-cells lymphopenia. Patients can develop B-cell lymphoproliferation associated with Epstein-Barr virus infection. {ECO:0000269PubMed:19097825, ECO:0000269PubMed:23522482}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008092	cytoskeletal protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0044822	poly(A) RNA binding
GO:0051015	actin filament binding

Biological Process

GO:0001845	phagolysosome assembly
GO:0006816	calcium ion transport
GO:0006909	phagocytosis
GO:0006928	cellular component movement
GO:0007015	actin filament organization
GO:0008064	regulation of actin polymerization or depolymerization
GO:0008360	regulation of cell shape
GO:0016477	cell migration
GO:0030036	actin cytoskeleton organization
GO:0030335	positive regulation of cell migration
GO:0030595	leukocyte chemotaxis
GO:0030833	regulation of actin filament polymerization
GO:0031589	cell-substrate adhesion
GO:0032796	uropod organization
GO:0034097	response to cytokine
GO:0042102	positive regulation of T cell proliferation
GO:0043029	T cell homeostasis
GO:0045087	innate immune response
GO:0048873	homeostasis of number of cells within a tissue
GO:0050870	positive regulation of T cell activation
GO:0050918	positive chemotaxis
GO:0051126	negative regulation of actin nucleation
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0001772	immunological synapse
GO:0001891	phagocytic cup
GO:0005737	cytoplasm
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030670	phagocytic vesicle membrane
GO:0030864	cortical actin cytoskeleton
GO:0031252	cell leading edge
GO:0043234	protein complex
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR015048 Domain of unknown function DUF1899
IPR015049 Domain of unknown function DUF1900
IPR017986 WD40-repeat-containing domain

PFAM

PF00400
PF08953
PF08954

PRINTS

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P31146