Version 5.4
Mus musculus Protein: Slamf7
Summary
InnateDB Protein IDBP-258478.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slamf7
Protein Name SLAM family member 7
Synonyms 19A; 19A24; 4930560D03Rik; CRACC; CS1;
Species Mus musculus
Ensembl Protein ENSMUSP00000106907
InnateDB Gene IDBG-204760 (Slamf7)
Protein Structure
UniProt Annotation
Function Mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Expressed in spleen, lymph node, bone marrow and testis. Lower levels detected in thymus. Expressed in NK cells and B-cells. {ECO:0000269PubMed:12242590}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0032814 regulation of natural killer cell activation
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1922595
InterPro IPR007110 Immunoglobulin-like domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BHK6
PhosphoSite PhosphoSite-Q8BHK6
TrEMBL
UniProt Splice Variant
Entrez Gene 75345
UniGene Mm.490386
RefSeq NP_653122
MGI ID
MGI Symbol Slamf7
OMIM
CCDS CCDS15500
HPRD
IMGT
EMBL AF467909 AF467910 AF467911 AK030135 AK030148 AK040678 AK089525 BC011154
GenPept AAH11154 AAN63158 AAN63159 AAN63160 BAC26801 BAC26810 BAC30665 BAC40914

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca