InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pea15a

Summary

InnateDB Protein

IDBP-258541.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pea15a

Protein Name

phosphoprotein enriched in astrocytes 15A

Synonyms

Mat1; PEA-15; Pea15; Pkcs15;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106878

InnateDB Gene

IDBG-205249 (Pea15a)

Protein Structure

UniProt Annotation

Function

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10926929}. Note=Associated with microtubules.

Disease Associations

Tissue Specificity

Predominantly expressed in the brain. Low levels in some peripheral organs.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0008643	carbohydrate transport
GO:0035556	intracellular signal transduction
GO:0042981	regulation of apoptotic process
GO:0043278	response to morphine
GO:0046325	negative regulation of glucose import
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors