Version 5.4
Mus musculus Protein: Dtx2
Summary
InnateDB Protein IDBP-258747.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dtx2
Protein Name deltex 2 homolog (Drosophila)
Synonyms 2610524D08Rik; AA408415; AU022494; Deltex2;
Species Mus musculus
Ensembl Protein ENSMUSP00000106774
InnateDB Gene IDBG-204220 (Dtx2)
Protein Structure
UniProt Annotation
Function Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}.
Disease Associations Note=Recurrent site of retroviral integration in murine B-cell lymphomas.
Tissue Specificity Expressed in testis and the CNS. {ECO:0000269PubMed:11226752}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0007219 Notch signaling pathway
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID MGI:1921448
InterPro IPR001841 Zinc finger, RING-type
IPR004170 WWE domain
IPR018123 WWE domain, subgroup
PFAM PF13639
PF14634
PF02825
PRINTS
PIRSF
SMART SM00184
SM00678
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R3P2
PhosphoSite PhosphoSite-Q8R3P2
TrEMBL
UniProt Splice Variant
Entrez Gene 74198
UniGene Mm.275574
RefSeq NP_001243026
MGI ID 1V87
MGI Symbol Dtx2
OMIM
CCDS CCDS57390
HPRD
IMGT
EMBL AB015423 AB015424 AK012137 AK044105 AK054443 BC024925
GenPept AAH24925 BAB18940 BAB18941 BAB28055 BAC31780 BAC35781

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca