Version 5.4
Mus musculus Protein: Cd59b
Summary
InnateDB Protein IDBP-258777.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd59b
Protein Name CD59b antigen
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000106760
InnateDB Gene IDBG-194273 (Cd59b)
Protein Structure
UniProt Annotation
Function Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Lipid-anchor, GPI-anchor.
Disease Associations
Tissue Specificity Widely expressed in the kidneys, brain, lungs, spleen and testis (PubMed:11471050) Testis specific (PubMed:10946279). {ECO:0000269PubMed:10946279, ECO:0000269PubMed:11471050}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001848 complement binding
Biological Process
GO:0001775 cell activation
GO:0001971 negative regulation of activation of membrane attack complex
GO:0007166 cell surface receptor signaling pathway
GO:0045916 negative regulation of complement activation
GO:0045918 negative regulation of cytolysis
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID MGI:1888996
InterPro IPR001526 CD59 antigen
IPR016054 Ly-6 antigen / uPA receptor -like
PFAM PF00021
PRINTS
PIRSF
SMART SM00134
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P58019
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 333883
UniGene Mm.359026
RefSeq
MGI ID
MGI Symbol Cd59b
OMIM
CCDS CCDS16486
HPRD
IMGT
EMBL AF292401 BC139203 BC145912 BC171969 BX640578 BX813317
GenPept AAI39204 AAI45913 AAI71969 AAL04434 CAM18975 CAM27769

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca