InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptk2b

Summary

InnateDB Protein

IDBP-258786.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Ptk2b

Protein Name

PTK2 protein tyrosine kinase 2 beta

Synonyms

CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2; FAK2; PYK2; Raftk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106750

InnateDB Gene

IDBG-175126 (Ptk2b)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	73 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0032403	protein complex binding
GO:0043423	3-phosphoinositide-dependent protein kinase binding

Biological Process

GO:0000165	MAPK cascade
GO:0000302	response to reactive oxygen species
GO:0001525	angiogenesis
GO:0001556	oocyte maturation
GO:0001666	response to hypoxia
GO:0001954	positive regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0006968	cellular defense response
GO:0006970	response to osmotic stress
GO:0007015	actin filament organization
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007172	signal complex assembly
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007229	integrin-mediated signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0009612	response to mechanical stimulus
GO:0009725	response to hormone
GO:0009749	response to glucose
GO:0010226	response to lithium ion
GO:0010243	response to organonitrogen compound
GO:0010595	positive regulation of endothelial cell migration
GO:0010656	negative regulation of muscle cell apoptotic process
GO:0010976	positive regulation of neuron projection development
GO:0014009	glial cell proliferation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030154	cell differentiation
GO:0030155	regulation of cell adhesion
GO:0030279	negative regulation of ossification
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0030838	positive regulation of actin filament polymerization
GO:0031175	neuron projection development
GO:0032863	activation of Rac GTPase activity
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035902	response to immobilization stress
GO:0038083	peptidyl-tyrosine autophosphorylation
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0042976	activation of Janus kinase activity
GO:0043066	negative regulation of apoptotic process
GO:0043149	stress fiber assembly
GO:0043267	negative regulation of potassium ion transport
GO:0043507	positive regulation of JUN kinase activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0043534	blood vessel endothelial cell migration
GO:0045471	response to ethanol
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045727	positive regulation of translation
GO:0045860	positive regulation of protein kinase activity
GO:0046330	positive regulation of JNK cascade
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048041	focal adhesion assembly
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051591	response to cAMP
GO:0051592	response to calcium ion
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0060291	long-term synaptic potentiation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071300	cellular response to retinoic acid
GO:2000058	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000379	positive regulation of reactive oxygen species metabolic process
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0014069	postsynaptic density
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030027	lamellipodium
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0043025	neuronal cell body
GO:0044297	cell body
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0097440	apical dendrite

Protein Structure and Domains

PDB ID

MGI:104908

InterPro

IPR000299 FERM domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR005189 Focal adhesion kinase, targeting (FAT) domain
IPR011009 Protein kinase-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR029071 Ubiquitin-related domain

PFAM

PF00069
PF07714
PF03623
PF00373

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00295
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt