InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hipk3

Summary

InnateDB Protein

IDBP-258790.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hipk3

Protein Name

homeodomain interacting protein kinase 3

Synonyms

DYRK6; FIST3; PKY;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106753

InnateDB Gene

IDBG-194397 (Hipk3)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF- responsive element (OCFRE). {ECO:0000269PubMed:11034606, ECO:0000269PubMed:17210646, ECO:0000269PubMed:20484411}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Heart, skeletal muscle, spleen, testis and lung. {ECO:0000269PubMed:11034606}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0009103	lipopolysaccharide biosynthetic process
GO:0009299	mRNA transcription
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0043388	positive regulation of DNA binding
GO:0043508	negative regulation of JUN kinase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016605	PML body

Protein Structure and Domains

PDB ID

MGI:1314882

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06293

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt