InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pnpla6

Summary

InnateDB Protein

IDBP-258895.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pnpla6

Protein Name

patatin-like phospholipase domain containing 6

Synonyms

AI661849; MSws; Nte;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106699

InnateDB Gene

IDBG-129826 (Pnpla6)

Protein Structure

UniProt Annotation

Function

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. {ECO:0000269PubMed:12640454, ECO:0000269PubMed:16963094}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:16963094}; Single-pass type I membrane protein {ECO:0000269PubMed:16963094}; Cytoplasmic side {ECO:0000269PubMed:16963094}. Note=Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment.

Disease Associations

Tissue Specificity

Expressed ubiquitously in brain of young mice. Reaching adulthood, there is a most prominent expression in Purkinje cells, granule cells and pyramidal neurons of the hippocampus and some large neurons in the medulla oblongata, nucleus dentatus and pons. {ECO:0000269PubMed:10640712}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004622	lysophospholipase activity
GO:0052689	carboxylic ester hydrolase activity

Biological Process

GO:0001525	angiogenesis
GO:0006629	lipid metabolic process
GO:0008152	metabolic process
GO:0009887	organ morphogenesis
GO:0016042	lipid catabolic process
GO:0046470	phosphatidylcholine metabolic process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1354723

InterPro

IPR000595 Cyclic nucleotide-binding domain
IPR002641 Patatin/Phospholipase A2-related
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR018490 Cyclic nucleotide-binding-like

PFAM

PF00027
PF01734

PRINTS

PIRSF

SMART

SM00100

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3TRM4