Version 5.4
Mus musculus Protein: Pilrb1
Summary
InnateDB Protein IDBP-259102.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pilrb1
Protein Name paired immunoglobin-like type 2 receptor beta 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000106606
InnateDB Gene IDBG-205552 (Pilrb1)
Protein Structure
UniProt Annotation
Function Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. Seems to associate with DAP12 and is a receptor for CD99. May be involved in target cell recognition by natural killer cells and in activation of dendritic cells. {ECO:0000269PubMed:14970179}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in spleen, liver and lung. Predominantly expressed by natural killer cells, macrophages, and granulocytes and dendritic cells (BM-DC). {ECO:0000269PubMed:14970179}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042288 MHC class I protein binding
Biological Process
GO:0001773 myeloid dendritic cell activation
GO:0045671 negative regulation of osteoclast differentiation
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2450532
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2YFS2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 170741
UniGene
RefSeq NP_573472
MGI ID
MGI Symbol Pilrb1
OMIM
CCDS CCDS51675
HPRD
IMGT
EMBL AB122024 AJ400847 AY823670
GenPept AAX39495 BAD12395 CAC19332

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca