InnateDB Protein
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IDBP-25925.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CD68
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Protein Name
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CD68 molecule
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Synonyms
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GP110; LAMP4; SCARD1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000250092
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InnateDB Gene
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IDBG-25923 (CD68)
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Protein Structure
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Function |
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
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Subcellular Localization |
Isoform Short: Cell membrane; Single-pass type I membrane protein.Isoform Long: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. {ECO:0000269PubMed:18405323}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
6
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002000
Lysosome-associated membrane glycoprotein
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PFAM |
PF01299
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PRINTS |
PR00336
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P34810
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PhosphoSite |
PhosphoSite-P34810
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TrEMBL |
B4DNT7
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UniProt Splice Variant |
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Entrez Gene |
968
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UniGene |
Hs.647419
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RefSeq |
NP_001242
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HUGO |
HGNC:1693
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OMIM |
153634
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CCDS |
CCDS11114
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HPRD |
01093
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IMGT |
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EMBL |
AC016876
AF060540
AK222492
AK222514
AK290238
AK298055
AK301223
BC015557
BT009923
CH471108
S57235
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GenPept |
AAB25811
AAC70006
AAH15557
AAP88925
BAD96212
BAD96234
BAF82927
BAG60349
BAG62796
EAW90165
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