InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acp1

Summary

InnateDB Protein

IDBP-259334.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acp1

Protein Name

acid phosphatase 1, soluble

Synonyms

4632432E04Rik; Acp-1; AI427468; LMW-PTP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106509

InnateDB Gene

IDBG-132679 (Acp1)

Protein Structure

UniProt Annotation

Function

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. {ECO:0000250UniProtKB:P11064}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in brain and liver and lowest levels in muscle. {ECO:0000269PubMed:9824304}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003993	acid phosphatase activity
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0035335

peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009898	cytoplasmic side of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:87881

InterPro

IPR000106 Protein-tyrosine phosphatase/arsenate reductase
IPR002115 Protein-tyrosine phosphatase, low molecular weight, mammalian
IPR023485 Phosphotyrosine protein phosphatase I superfamily

PFAM

PF01451

PRINTS

PR00719
PR00720

PIRSF

SMART

SM00226

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt