InnateDB Protein
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IDBP-25941.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MESDC2
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Protein Name
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mesoderm development candidate 2
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Synonyms
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BOCA; MESD;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000261758
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InnateDB Gene
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IDBG-25939 (MESDC2)
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Protein Structure
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Function |
Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. {ECO:0000269PubMed:15014448, ECO:0000269PubMed:17488095}.
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Subcellular Localization |
Endoplasmic reticulum {ECO:0000269PubMed:15014448, ECO:0000269PubMed:17488095}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
20
[view]
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Protein-Protein |
20
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019330
Mesoderm development candidate 2
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PFAM |
PF10185
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14696
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PhosphoSite |
PhosphoSite-Q14696
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
23184
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UniGene |
Hs.732380
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RefSeq |
NP_055969
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HUGO |
HGNC:13520
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OMIM |
607783
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CCDS |
CCDS32308
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HPRD |
12129
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IMGT |
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EMBL |
AY359110
BC009210
BC012746
CH471136
D42039
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GenPept |
AAH09210
AAH12746
AAQ89468
BAA07640
EAW99109
EAW99110
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