InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mad1l1

Summary

InnateDB Protein

IDBP-259416.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mad1l1

Protein Name

mitotic arrest deficient 1-like 1

Synonyms

AI173502; AW550425; Mad1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106453

InnateDB Gene

IDBG-206816 (Mad1l1)

Protein Structure

UniProt Annotation

Function

Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Colocalizes with NEK2 at the kinetochore (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	7 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007067	mitotic nuclear division
GO:0007094	mitotic spindle assembly checkpoint
GO:0090235	regulation of metaphase plate congression

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005643	nuclear pore
GO:0005739	mitochondrion
GO:0005815	microtubule organizing center
GO:0015629	actin cytoskeleton
GO:0072686	mitotic spindle

Protein Structure and Domains

PDB ID

MGI:1341857

InterPro

IPR008672 Spindle assembly checkpoint component Mad1

PFAM

PF05557

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WTX8

PhosphoSite

PhosphoSite-Q9WTX8

TrEMBL

UniProt Splice Variant

Entrez Gene

17120

UniGene

Mm.27250

RefSeq

MGI ID

MGI Symbol

Mad1l1

OMIM

CCDS

HPRD

IMGT

EMBL

AF083812 AF083813 BC010702

GenPept

AAD24499 AAD24500 AAH10702